Cargando…

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes inflammation via trained immunity (TI). We found that endoplasmic reticulum (ER) stress genes were coupregulated with MitoCarta genes in chr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saaoud, Fatma, Liu, Lu, Xu, Keman, Cueto, Ramon, Shao, Ying, Lu, Yifan, Sun, Yu, Snyder, Nathaniel W., Wu, Sheng, Yang, Ling, Zhou, Yan, Williams, David L., Li, Chuanfu, Martinez, Laisel, Vazquez-Padron, Roberto I., Zhao, Huaqing, Jiang, Xiaohua, Wang, Hong, Yang, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870092/ https://www.ncbi.nlm.nih.gov/pubmed/36394956 http://dx.doi.org/10.1172/jci.insight.158183

Ejemplares similares

ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development
por: Lu, Yifan, et al.
Publicado: (2023)

Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis
por: Xu, Keman, et al.
Publicado: (2023)

Editorial: Debates in cardiovascular pharmacology and drug discovery: 2022
por: Xu, Keman, et al.
Publicado: (2023)

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages
por: Drummer, Charles, et al.
Publicado: (2023)

Chronic Kidney Disease Transdifferentiates Veins into a Specialized Immune–Endocrine Organ with Increased MYCN-AP1 Signaling
por: Saaoud, Fatma, et al.
Publicado: (2023)

Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation
por: Lu, Yifan, et al.
Publicado: (2021)

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
por: Sun, Yu, et al.
Publicado: (2020)

Editorial: Insights in cardiovascular therapeutics 2022—cardiovascular innate immunity
por: Xu, Keman, et al.
Publicado: (2023)

Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans-Differentiation—Early Secretomes may Serve as Drivers for Trained Immunity
por: Lu, Yifan, et al.
Publicado: (2022)

Cigarette Smoke and Morphine Promote Treg Plasticity to Th17 via Enhancing Trained Immunity
por: Shao, Ying, et al.
Publicado: (2022)

Editorial: Endothelial cells as innate immune cells
por: Lu, Yifan, et al.
Publicado: (2022)

Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance
por: Yang, Qian, et al.
Publicado: (2021)

29 m(6)A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses
por: Liu, Ming, et al.
Publicado: (2022)

IL-35 promotes CD4(+)Foxp3(+) Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms
por: Shao, Ying, et al.
Publicado: (2021)

Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways
por: Ni, Dong, et al.
Publicado: (2021)

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism
por: Shao, Ying, et al.
Publicado: (2021)

End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression
por: Zhang, Ruijing, et al.
Publicado: (2020)

Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD
por: Drummer, Charles I. V., et al.
Publicado: (2021)

A Novel Subset of CD95(+) Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity
por: Johnson, Candice, et al.
Publicado: (2021)

Novel Knowledge-Based Transcriptomic Profiling of Lipid Lysophosphatidylinositol-Induced Endothelial Cell Activation
por: Xu, Keman, et al.
Publicado: (2021)

Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis
por: Fu, Hangfei, et al.
Publicado: (2020)

Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators
por: Liu, Ming, et al.
Publicado: (2020)

Editorial: Insights in cardiovascular therapeutics: 2021 – cell death, cardiovascular injuries, and novel targets of cardiovascular therapeutics
por: Xu, Keman, et al.
Publicado: (2022)

Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung
por: Wang, Zijing, et al.
Publicado: (2021)

Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair
por: Zhang, Ruijing, et al.
Publicado: (2021)

TMAO: a potential mediator of clopidogrel resistance
por: Ma, Ruisong, et al.
Publicado: (2021)

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice
por: Fagenson, Alexander M., et al.
Publicado: (2020)

Oxamate Attenuates Glycolysis and ER Stress in Silicotic Mice
por: Mao, Na, et al.
Publicado: (2022)

Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators
por: Liu, Ming, et al.
Publicado: (2021)

Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
por: Chen, Ming-liang, et al.
Publicado: (2016)

Chronic Exposure to the Combination of Cigarette Smoke and Morphine Decreases CD4(+) Regulatory T Cell Numbers by Reprogramming the Treg Cell Transcriptome
por: Shao, Ying, et al.
Publicado: (2022)

Trimethylamine N-oxide (TMAO) in human health
por: Gatarek, Paulina, et al.
Publicado: (2021)

Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER Stress-CHOP Pathway
por: Cao, Qiongqiong, et al.
Publicado: (2021)

Age-related changes in monocytes exacerbate neointimal hyperplasia after vascular injury
por: Martinez, Laisel, et al.
Publicado: (2015)

Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells
por: Qin, Wenjie, et al.
Publicado: (2015)

Periadventitial β-aminopropionitrile-loaded nanofibers reduce fibrosis and improve arteriovenous fistula remodeling in rats
por: Applewhite, Brandon, et al.
Publicado: (2023)

Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma
por: Xu, Zhongren, et al.
Publicado: (2022)

High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction
por: Singh, Gurinder Bir, et al.
Publicado: (2019)

Gut Microbiota Dysbiosis and Increased Plasma LPS and TMAO Levels in Patients With Preeclampsia
por: Wang, Jing, et al.
Publicado: (2019)

Background Diet Influences TMAO Concentrations Associated with Red Meat Intake without Influencing Apparent Hepatic TMAO-Related Activity in a Porcine Model
por: Thøgersen, Rebekka, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_sb4nqrg7ell6sedqg7ppjhp577