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SIK3 and Wnk converge on Fray to regulate glial K(+) buffering and seizure susceptibility
Glial cells play a critical role in maintaining homeostatic ion concentration gradients. Salt-inducible kinase 3 (SIK3) regulates a gene expression program that controls K(+) buffering in glia, and upregulation of this pathway suppresses seizure behavior in the eag, Shaker hyperexcitability mutant....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870106/ https://www.ncbi.nlm.nih.gov/pubmed/36626385 http://dx.doi.org/10.1371/journal.pgen.1010581 |