Novel Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as selective Cyclooxygenase-2 Inhibitors: Design, synthesis, docking studies, and biological evaluation

The present study was aimed at the synthesis and evaluation of a new series of benzo[4,5]imidazo[1,2-a]pyrimidine having a methylsulfonyl group as COX-2 (cyclooxygenase-2) inhibitor pharmacophore. Molecular modeling studies were performed using the Autodock program, and the results demonstrated that...

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Detalles Bibliográficos
Autores principales: Bayanati, Maryam, Khoramjouy, Mona, Faizi, Mehrdad, Movahed, Mahsa Azami, Mahboubi-Rabbani, Mohammad, Zarghi, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870662/
https://www.ncbi.nlm.nih.gov/pubmed/36713891
http://dx.doi.org/10.1007/s00044-023-03022-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870662/
https://www.ncbi.nlm.nih.gov/pubmed/36713891
http://dx.doi.org/10.1007/s00044-023-03022-0

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