Metabolic rewiring in MYC-driven medulloblastoma by BET-bromodomain inhibition

Medulloblastoma (MB) is the most common malignant brain tumour in children. High-risk MB patients harbouring MYC amplification or overexpression exhibit a very poor prognosis. Aberrant activation of MYC markedly reprograms cell metabolism to sustain tumorigenesis, yet how metabolism is dysregulated...

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Detalles Bibliográficos
Autores principales: Graziani, Vittoria, Garcia, Aida Rodriguez, Alcolado, Lourdes Sainero, Le Guennec, Adrien, Henriksson, Marie Arsenian, Conte, Maria R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870962/
https://www.ncbi.nlm.nih.gov/pubmed/36690651
http://dx.doi.org/10.1038/s41598-023-27375-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870962/
https://www.ncbi.nlm.nih.gov/pubmed/36690651
http://dx.doi.org/10.1038/s41598-023-27375-z

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