PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation

Autophagy dysfunction is one of the common causes of tumor formation and plays an important role in uveal melanoma (UM). However, little is known about the regulatory mechanisms of autophagy in UM. Here, we show that PTK6 can promote the proliferation, migration, and invasion of UM cells by inhibiti...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Bo, Yao, Xueting, Zhang, Chaoyang, Liu, Yufen, Wei, Li, Huang, Qinying, Wang, Mengting, Zhang, Yanchen, Hu, Danning, Wu, Wencan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870980/
https://www.ncbi.nlm.nih.gov/pubmed/36690663
http://dx.doi.org/10.1038/s41419-023-05590-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870980/
https://www.ncbi.nlm.nih.gov/pubmed/36690663
http://dx.doi.org/10.1038/s41419-023-05590-w

Ejemplares similares