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Duck gasdermin E is a substrate of caspase-3/-7 and an executioner of pyroptosis

Gasdermin (GSDM)-mediated cell death is an ancient immune defensive mechanism that plays an essential role in bacteria, fungi, coral, teleost, and mammals. After being cleaved by proteases of hosts or pathogens, amino-terminal (NT) fragment of GSDMs (GSDM-NTs) form pores in the membrane structure of...

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Detalles Bibliográficos
Autores principales: Li, Hanqing, Wang, Xin, Yu, Lanjie, Wang, Junwei, Cao, Yongsheng, Ma, Bo, Zhang, Wenlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871645/
https://www.ncbi.nlm.nih.gov/pubmed/36703987
http://dx.doi.org/10.3389/fimmu.2022.1078526