Generation of bispecific antibodies by structure-guided redesign of IgG constant regions

Bispecific antibodies (BsAbs) form an exciting class of bio-therapeutics owing to their multispecificity. Although numerous formats have been developed, generation of hetero-tetrameric IgG1-like BsAbs having acceptable safety and pharmacokinetics profiles from a single cell culture system remains ch...

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Detalles Bibliográficos
Autores principales: Iwasaki, Yordkhwan W., Tharakaraman, Kannan, Subramanian, Vidya, Khongmanee, Amnart, Hatas, Andrew, Fleischer, Eduardo, Rurak, Troy T., Ngok-ngam, Patchara, Tit-oon, Phanthakarn, Ruchirawat, Mathuros, Satayavivad, Jutamaad, Fuangthong, Mayuree, Sasisekharan, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871890/
https://www.ncbi.nlm.nih.gov/pubmed/36703993
http://dx.doi.org/10.3389/fimmu.2022.1063002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871890/
https://www.ncbi.nlm.nih.gov/pubmed/36703993
http://dx.doi.org/10.3389/fimmu.2022.1063002

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