Cargando…

Generation of bispecific antibodies by structure-guided redesign of IgG constant regions

Bispecific antibodies (BsAbs) form an exciting class of bio-therapeutics owing to their multispecificity. Although numerous formats have been developed, generation of hetero-tetrameric IgG1-like BsAbs having acceptable safety and pharmacokinetics profiles from a single cell culture system remains ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iwasaki, Yordkhwan W., Tharakaraman, Kannan, Subramanian, Vidya, Khongmanee, Amnart, Hatas, Andrew, Fleischer, Eduardo, Rurak, Troy T., Ngok-ngam, Patchara, Tit-oon, Phanthakarn, Ruchirawat, Mathuros, Satayavivad, Jutamaad, Fuangthong, Mayuree, Sasisekharan, Ram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871890/ https://www.ncbi.nlm.nih.gov/pubmed/36703993 http://dx.doi.org/10.3389/fimmu.2022.1063002

Ejemplares similares

Intact mass analysis reveals the novel O-linked glycosylation on the stalk region of PD-1 protein
por: Tit-oon, Phanthakarn, et al.
Publicado: (2023)

Modified recombinant human erythropoietin with potentially reduced immunogenicity
por: Susantad, Thanutsorn, et al.
Publicado: (2021)

Prediction of the structural interface between fibroblast growth factor23 and Burosumab using alanine scanning and molecular docking
por: Kanhasut, Karnpob, et al.
Publicado: (2022)

Prediction of the binding interface between monoclonal antibody m102.4 and Nipah attachment glycoprotein using structure-guided alanine scanning and computational docking
por: Tit-oon, Phanthakarn, et al.
Publicado: (2020)

Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y CELLS
por: Ngok-Ngam, Patchara, et al.
Publicado: (2012)

Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles
por: Artpradit, Charlermchai, et al.
Publicado: (2013)

Vasorelaxant and Antioxidant Activities of Spilanthes acmella Murr.
por: Wongsawatkul, Orapin, et al.
Publicado: (2008)

Enhancing antibody affinity through experimental sampling of non-deleterious CDR mutations predicted by machine learning
por: Clark, Thomas, et al.
Publicado: (2023)

Glycan–protein interactions in viral pathogenesis
por: Raman, Rahul, et al.
Publicado: (2016)

Integrative In Silico and In Vitro Transcriptomics Analysis Revealed Gene Expression Changes and Oncogenic Features of Normal Cholangiocytes after Chronic Alcohol Exposure
por: Chujan, Suthipong, et al.
Publicado: (2019)

Identification of Potential Molecular Mechanisms and Prognostic Markers for Oral Squamous Cell Carcinoma: A Bioinformatics Analysis
por: Chujan, Suthipong, et al.
Publicado: (2023)

An inter-residue network model to identify mutational-constrained regions on the Ebola coat glycoprotein
por: Quinlan, Devin S., et al.
Publicado: (2017)

Integrated Transcriptomics and Network Analysis of Potential Mechanisms and Health Effects of Convalescent COVID-19 Patients
por: Chujan, Suthipong, et al.
Publicado: (2023)

Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic
por: Tharakaraman, Kannan, et al.
Publicado: (2013)

Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm.f.) Nees (Chuanxinlian)
por: Pholphana, Nanthanit, et al.
Publicado: (2013)

Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway
por: AMONYINGCHAROEN, SUMET, et al.
Publicado: (2015)

Potential candidate treatment agents for targeting of cholangiocarcinoma identified by gene expression profile analysis
por: Chujan, Suthipong, et al.
Publicado: (2018)

A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease
por: Songvut, Phanit, et al.
Publicado: (2022)

Mechanisms of Melatonin in Alleviating Alzheimer’s Disease
por: Shukla, Mayuri, et al.
Publicado: (2017)

Potentiation of TRAIL-Induced Apoptosis in TRAIL-Resistant Cholangiocarcinoma Cells by Curcumin through the Induction of DR5 Membrane Localization and Disruption of the Anti-Apoptotic Complex DR5/DDX3/GSK3β
por: Visitnonthachai, Daranee, et al.
Publicado: (2023)

Elevated ITGA2 expression promotes collagen type I-induced clonogenic growth of intrahepatic cholangiocarcinoma
por: Rattanasinchai, Chotirat, et al.
Publicado: (2022)

Regulation of Organic Hydroperoxide Stress Response by Two OhrR Homologs in Pseudomonas aeruginosa
por: Atichartpongkul, Sopapan, et al.
Publicado: (2016)

The Curious Case of Cholangiocarcinoma: Opportunities for Environmental Health Scientists to Learn about a Complex Disease
por: Suk, William A., et al.
Publicado: (2018)

Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset
por: Sasisekharan, Varun, et al.
Publicado: (2021)

A validated LC–MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata extract
por: Songvut, Phanit, et al.
Publicado: (2023)

Glycoproteomic Analysis Reveals Aberrant Expression of Complement C9 and Fibronectin in the Plasma of Patients with Colorectal Cancer
por: Chantaraamporn, Juthamard, et al.
Publicado: (2020)

Redesigning Animation
por: Bottini, Cinzia
Publicado: (2018)

Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants
por: Songvut, Phanit, et al.
Publicado: (2023)

Arsenic induces the global hypophosphorylation of insulin receptor substrate proteins in differentiated human neuroblastoma SH-SY5Y cells
por: Wisessaowapak, Churaibhon, et al.
Publicado: (2023)

NSIT: Novel Sequence Identification Tool
por: Pupacdi, Benjarath, et al.
Publicado: (2014)

Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B(6)C(3)F(1) mice
por: Tangjarukij, Chanthana, et al.
Publicado: (2021)

Pseudomonas aeruginosa ttcA encoding tRNA-thiolating protein requires an iron-sulfur cluster to participate in hydrogen peroxide-mediated stress protection and pathogenicity
por: Romsang, Adisak, et al.
Publicado: (2018)

Acute oral toxicity evaluation of Andrographis paniculata-standardized first true leaf ethanolic extract
por: Worasuttayangkurn, Luksamee, et al.
Publicado: (2019)

Redesigning the psychiatry induction
por: Wisidagama, Sharadha, et al.
Publicado: (2021)

Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513
por: Wong, Yee Hwa, et al.
Publicado: (2018)

In utero arsenic exposure increases DNA damage and gene expression changes in umbilical cord mesenchymal stem cells (UC-MSCs) from newborns as well as in UC-MSC differentiated hepatocytes
por: Kantisin, Siriwan, et al.
Publicado: (2022)

AIDA MIND redesign status
por: Noah, E, et al.
Publicado: (2015)

Redesign your library website
por: Wittmann, Stacy Ann, et al.
Publicado: (2016)

Redesigning the Post-Pandemic Workplace
por: Kane, Gerald, et al.
Publicado: (2021)

Redesigning antidepressant drug discovery
por: Holsboer, Florian
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_l06k95asi35jotkdcctsaqjohe