Validation and application of a quantitative liquid chromatography tandem mass spectrometry assay for the analysis of rifapentine and 25-O-desacetyl rifapentine in human milk

A robust analytical method based on liquid chromatography coupled to tandem mass spectrometry was developed and validated to quantify rifapentine and 25-O-desacetyl rifapentine in human breast milk to aid in determining the breastfed infant risk to the excreted drug in human milk. Samples were extra...

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Detalles Bibliográficos
Autores principales: Mkhize, Buyisile, Kellermann, Tracy, Norman, Jennifer, Castel, Sandra, Joubert, Anton, van der Merwe, Marthinus, Dooley, Kelly E., Mathad, Jyoti S., Wiesner, Lubbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871952/
https://www.ncbi.nlm.nih.gov/pubmed/35462285
http://dx.doi.org/10.1016/j.jpba.2022.114774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871952/
https://www.ncbi.nlm.nih.gov/pubmed/35462285
http://dx.doi.org/10.1016/j.jpba.2022.114774

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