Chemoselective Ru-Catalyzed Oxidative Lactamization vs Hydroamination of Alkynylamines: Insights from Experimental and Density Functional Theory Studies

[Image: see text] The Ru-catalyzed intramolecular oxidative amidation (lactamization) of aromatic alkynylamines with 4-picoline N-oxide as an external oxidant has been developed. This chemoselective process is very efficient to achieve medium-sized ε- and ζ-lactams (seven- and eight-membered rings)...

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Detalles Bibliográficos
Autores principales: Álvarez-Constantino, Andrés M., Álvarez-Pérez, Andrea, Varela, Jesús A., Sciortino, Giuseppe, Ujaque, Gregori, Saá, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872091/
https://www.ncbi.nlm.nih.gov/pubmed/36579612
http://dx.doi.org/10.1021/acs.joc.2c02770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872091/
https://www.ncbi.nlm.nih.gov/pubmed/36579612
http://dx.doi.org/10.1021/acs.joc.2c02770

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