Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy

INTRODUCTION: The use of tumor subcutaneous (SC) implantations rather than orthotopic sites is likely to induce a significant bias, in particular, in the field of immunotherapy. METHODS: In this study, we developed and characterized MC38 models, implanted subcutaneously and orthotopically, which wer...

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Detalles Bibliográficos
Autores principales: Denis, Morgane, Mathé, Doriane, Micoud, Manon, Choffour, Pierre-Antoine, Grasselly, Chloé, Matera, Eva-Laure, Dumontet, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872099/
https://www.ncbi.nlm.nih.gov/pubmed/36703964
http://dx.doi.org/10.3389/fimmu.2022.1011943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872099/
https://www.ncbi.nlm.nih.gov/pubmed/36703964
http://dx.doi.org/10.3389/fimmu.2022.1011943

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