Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines

[Image: see text] The identification of the beneficial pharmacokinetic properties of aza-spirocycles has led to the routine incorporation of these highly rigid and three-dimensional structures in pharmaceuticals. Herein, we report an operationally simple synthesis of spirocyclic dihydropyridines via...

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Detalles Bibliográficos
Autores principales: Abell, Joseph C., Bold, Christian P., Vicens, Laia, Jentsch, Tom, Velasco, Noelia, Tyler, Jasper L., Straker, Robert N., Noble, Adam, Aggarwal, Varinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872164/
https://www.ncbi.nlm.nih.gov/pubmed/36626565
http://dx.doi.org/10.1021/acs.orglett.2c04095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872164/
https://www.ncbi.nlm.nih.gov/pubmed/36626565
http://dx.doi.org/10.1021/acs.orglett.2c04095

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