Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited therapeutic options. However, metabolic adaptation to the harsh PDAC environment can expose liabilities useful for therapy. Targeting the key metabolic regulator mechanistic target of rapamycin complex 1 (mTORC1...

Descripción completa

Detalles Bibliográficos
Autores principales: De Santis, Maria Chiara, Gozzelino, Luca, Margaria, Jean Piero, Costamagna, Andrea, Ratto, Edoardo, Gulluni, Federico, Di Gregorio, Enza, Mina, Erica, Lorito, Nicla, Bacci, Marina, Lattanzio, Rossano, Sala, Gianluca, Cappello, Paola, Novelli, Francesco, Giovannetti, Elisa, Vicentini, Caterina, Andreani, Silvia, Delfino, Pietro, Corbo, Vincenzo, Scarpa, Aldo, Porporato, Paolo Ettore, Morandi, Andrea, Hirsch, Emilio, Martini, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872233/
https://www.ncbi.nlm.nih.gov/pubmed/35623884
http://dx.doi.org/10.1136/gutjnl-2021-325117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872233/
https://www.ncbi.nlm.nih.gov/pubmed/35623884
http://dx.doi.org/10.1136/gutjnl-2021-325117

Ejemplares similares