Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases

OBJECTIVE: Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive cellular therapy have had limited success in patients with microsatellite stable colorectal cancer liver metastases (CRLM). We sought to evaluate the effect of interleukin 10 (IL-10) blockade on endogenous T cell an...

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Detalles Bibliográficos
Autores principales: Sullivan, Kevin M, Jiang, Xiuyun, Guha, Prajna, Lausted, Christopher, Carter, Jason A, Hsu, Cynthia, Labadie, Kevin P, Kohli, Karan, Kenerson, Heidi L, Daniel, Sara K, Yan, Xiaowei, Meng, Changting, Abbasi, Arezou, Chan, Marina, Seo, Y David, Park, James O, Crispe, Ian Nicholas, Yeung, Raymond S, Kim, Teresa S, Gujral, Taranjit S, Tian, Qiang, Katz, Steven C, Pillarisetty, Venu G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872249/
https://www.ncbi.nlm.nih.gov/pubmed/35705369
http://dx.doi.org/10.1136/gutjnl-2021-325808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872249/
https://www.ncbi.nlm.nih.gov/pubmed/35705369
http://dx.doi.org/10.1136/gutjnl-2021-325808

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