Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19

Adintrevimab is a human immunoglobulin G1 monoclonal antibody engineered to have broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and other SARS-like coronaviruses with pandemic potential. In both Syrian golden hamster and rhesus macaque models, prop...

Descripción completa

Detalles Bibliográficos
Autores principales: Zumbrun, Elizabeth E., Kaku, Chengzi I., Dillinger, Lukas, Zak, Samantha E., Kuehne, Ana I., Bakken, Russel R., Koehler, Jeffrey W., Delp, Korey L., Stefan, Christopher P., Kumar, Raina, Kugelman, Jeffrey R., Moreau, Alicia M., Zeng, Xiankun, Dye, John M., Herbert, Andrew S., Narayan, Kristin, Walker, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872613/
https://www.ncbi.nlm.nih.gov/pubmed/36519929
http://dx.doi.org/10.1128/aac.01353-22
_version_ 1784877441219559424
author Zumbrun, Elizabeth E.
Kaku, Chengzi I.
Dillinger, Lukas
Zak, Samantha E.
Kuehne, Ana I.
Bakken, Russel R.
Koehler, Jeffrey W.
Delp, Korey L.
Stefan, Christopher P.
Kumar, Raina
Kugelman, Jeffrey R.
Moreau, Alicia M.
Zeng, Xiankun
Dye, John M.
Herbert, Andrew S.
Narayan, Kristin
Walker, Laura M.
author_facet Zumbrun, Elizabeth E.
Kaku, Chengzi I.
Dillinger, Lukas
Zak, Samantha E.
Kuehne, Ana I.
Bakken, Russel R.
Koehler, Jeffrey W.
Delp, Korey L.
Stefan, Christopher P.
Kumar, Raina
Kugelman, Jeffrey R.
Moreau, Alicia M.
Zeng, Xiankun
Dye, John M.
Herbert, Andrew S.
Narayan, Kristin
Walker, Laura M.
author_sort Zumbrun, Elizabeth E.
collection PubMed
description Adintrevimab is a human immunoglobulin G1 monoclonal antibody engineered to have broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and other SARS-like coronaviruses with pandemic potential. In both Syrian golden hamster and rhesus macaque models, prophylactic administration of a single dose of adintrevimab provided protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner, as measured by significant reductions in lung viral load and virus-induced lung pathology, and by inhibition of viral replication in the upper and lower respiratory tract.
format Online
Article
Text
id pubmed-9872613
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-98726132023-01-25 Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19 Zumbrun, Elizabeth E. Kaku, Chengzi I. Dillinger, Lukas Zak, Samantha E. Kuehne, Ana I. Bakken, Russel R. Koehler, Jeffrey W. Delp, Korey L. Stefan, Christopher P. Kumar, Raina Kugelman, Jeffrey R. Moreau, Alicia M. Zeng, Xiankun Dye, John M. Herbert, Andrew S. Narayan, Kristin Walker, Laura M. Antimicrob Agents Chemother Antiviral Agents Adintrevimab is a human immunoglobulin G1 monoclonal antibody engineered to have broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and other SARS-like coronaviruses with pandemic potential. In both Syrian golden hamster and rhesus macaque models, prophylactic administration of a single dose of adintrevimab provided protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner, as measured by significant reductions in lung viral load and virus-induced lung pathology, and by inhibition of viral replication in the upper and lower respiratory tract. American Society for Microbiology 2022-12-15 /pmc/articles/PMC9872613/ /pubmed/36519929 http://dx.doi.org/10.1128/aac.01353-22 Text en Copyright © 2022 American Society for Microbiology. https://doi.org/10.1128/ASMCopyrightv2All Rights Reserved (https://doi.org/10.1128/ASMCopyrightv2) . https://doi.org/10.1128/ASMCopyrightv2This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Antiviral Agents
Zumbrun, Elizabeth E.
Kaku, Chengzi I.
Dillinger, Lukas
Zak, Samantha E.
Kuehne, Ana I.
Bakken, Russel R.
Koehler, Jeffrey W.
Delp, Korey L.
Stefan, Christopher P.
Kumar, Raina
Kugelman, Jeffrey R.
Moreau, Alicia M.
Zeng, Xiankun
Dye, John M.
Herbert, Andrew S.
Narayan, Kristin
Walker, Laura M.
Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19
title Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19
title_full Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19
title_fullStr Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19
title_full_unstemmed Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19
title_short Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19
title_sort prophylactic administration of the monoclonal antibody adintrevimab protects against sars-cov-2 in hamster and non-human primate models of covid-19
topic Antiviral Agents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872613/
https://www.ncbi.nlm.nih.gov/pubmed/36519929
http://dx.doi.org/10.1128/aac.01353-22
work_keys_str_mv AT zumbrunelizabethe prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT kakuchengzii prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT dillingerlukas prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT zaksamanthae prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT kuehneanai prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT bakkenrusselr prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT koehlerjeffreyw prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT delpkoreyl prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT stefanchristopherp prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT kumarraina prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT kugelmanjeffreyr prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT moreaualiciam prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT zengxiankun prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT dyejohnm prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT herbertandrews prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT narayankristin prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19
AT walkerlauram prophylacticadministrationofthemonoclonalantibodyadintrevimabprotectsagainstsarscov2inhamsterandnonhumanprimatemodelsofcovid19

Ejemplares similares