Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses

Design of novel β-lactamase inhibitors (BLIs) is one of the currently accepted strategies to combat the threat of cephalosporin and carbapenem resistance in Gram-negative bacteria. Boronic acid transition state inhibitors (BATSIs) are competitive, reversible BLIs that offer promise as novel therapeu...

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Detalles Bibliográficos
Autores principales: Alsenani, Tahani A., Rodríguez, María Margarita, Ghiglione, Barbara, Taracila, Magdalena A., Mojica, Maria F., Rojas, Laura J., Hujer, Andrea M., Gutkind, Gabriel, Bethel, Christopher R., Rather, Philip N., Introvigne, Maria Luisa, Prati, Fabio, Caselli, Emilia, Power, Pablo, van den Akker, Focco, Bonomo, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872677/
https://www.ncbi.nlm.nih.gov/pubmed/36602311
http://dx.doi.org/10.1128/aac.00930-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872677/
https://www.ncbi.nlm.nih.gov/pubmed/36602311
http://dx.doi.org/10.1128/aac.00930-22

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