Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

The clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As mAb-based drugs are becoming more prevalent in the treatme...

Descripción completa

Detalles Bibliográficos
Autores principales: Solomon, Tsega L., Delaglio, Frank, Giddens, John P., Marino, John P., Yu, Yihua Bruce, Taraban, Marc B., Brinson, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872951/
https://www.ncbi.nlm.nih.gov/pubmed/36683157
http://dx.doi.org/10.1080/19420862.2022.2160227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872951/
https://www.ncbi.nlm.nih.gov/pubmed/36683157
http://dx.doi.org/10.1080/19420862.2022.2160227

Ejemplares similares