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Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb
The clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As mAb-based drugs are becoming more prevalent in the treatme...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872951/ https://www.ncbi.nlm.nih.gov/pubmed/36683157 http://dx.doi.org/10.1080/19420862.2022.2160227 |