Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning

Despite the advances in surface-display systems for directed evolution, variants with high affinity are not always enriched due to undesirable biases that increase target-unrelated variants during biopanning. Here, our goal was to design a library containing improved variants from the information of...

Descripción completa

Detalles Bibliográficos
Autores principales: Ito, Tomoyuki, Nguyen, Thuy Duong, Saito, Yutaka, Kurumida, Yoichi, Nakazawa, Hikaru, Kawada, Sakiya, Nishi, Hafumi, Tsuda, Koji, Kameda, Tomoshi, Umetsu, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872955/
https://www.ncbi.nlm.nih.gov/pubmed/36683172
http://dx.doi.org/10.1080/19420862.2023.2168470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872955/
https://www.ncbi.nlm.nih.gov/pubmed/36683172
http://dx.doi.org/10.1080/19420862.2023.2168470

Ejemplares similares