Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer’s circuit dysfunction

Neurodegenerative diseases are characterized by selective vulnerability of distinct cell populations; however, the cause for this specificity remains elusive. Here, we show that entorhinal cortex layer 2 (EC2) neurons are unusually vulnerable to prolonged neuronal inactivity compared with neighborin...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Rong, Grunke, Stacy D, Wood, Caleb A, Perez, Gabriella A, Comstock, Melissa, Li, Ming-Hua, Singh, Anand K, Park, Kyung-Won, Jankowsky, Joanna L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873254/
https://www.ncbi.nlm.nih.gov/pubmed/36468693
http://dx.doi.org/10.7554/eLife.83813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873254/
https://www.ncbi.nlm.nih.gov/pubmed/36468693
http://dx.doi.org/10.7554/eLife.83813

Ejemplares similares