Cargando…

A Phase II Study of Preoperative Chemoradiotherapy with Capecitabine Plus Simvastatin in Patients with Locally Advanced Rectal Cancer

PURPOSE: The purpose of this phase II trial was to evaluate whether the addition of simvastatin, a synthetic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, to preoperative chemoradiotherapy (CRT) with capecitabine confers a clinical benefit to patients with locally advanced rectal cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jo, Hyunji, Kim, Seung Tae, Lee, Jeeyun, Park, Se Hoon, Park, Joon Oh, Park, Young Suk, Lim, Ho Yeong, Yu, Jeong Il, Park, Hee Chul, Choi, Doo Ho, Park, Yoonah, Cho, Yong Beom, Huh, Jung Wook, Yun, Seong Hyeon, Kim, Hee Cheol, Lee, Woo Yong, Kang, Won Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Cancer Association 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873315/ https://www.ncbi.nlm.nih.gov/pubmed/35681110 http://dx.doi.org/10.4143/crt.2021.1527

Ejemplares similares

Correlation between T stage and lymph node metastasis in rectal cancer treated with preoperative chemoradiotherapy
por: Kim, Seijong, et al.
Publicado: (2022)

Effect of leukocyte alteration on treatment outcomes following preoperative chemoradiotherapy in patients with rectal cancer
por: Kim, Tae Gyu, et al.
Publicado: (2017)

Comparison of two preoperative chemoradiotherapy regimens for locally advanced rectal cancer: capecitabine alone versus capecitabine plus irinotecan
por: Lee, Sung Uk, et al.
Publicado: (2013)

Negative impact of pretreatment anemia on local control after neoadjuvant chemoradiotherapy and surgery for rectal cancer
por: Lee, Hyebin, et al.
Publicado: (2012)

Predicting multi-class responses to preoperative chemoradiotherapy in rectal cancer patients
por: Gim, Jungsoo, et al.
Publicado: (2016)

Immunohistochemical Detection of p53 Expression in Patients with Preoperative Chemoradiation for Rectal Cancer: Association with Prognosis
por: Huh, Jung Wook, et al.
Publicado: (2015)

Mismatch Repair Gene Expression as a Predictor of Tumor Responses in Patients With Rectal Cancer Treated With Preoperative Chemoradiation
por: Huh, Jung Wook, et al.
Publicado: (2016)

Clinical prediction model of pathological response following neoadjuvant chemoradiotherapy for rectal cancer
por: Shin, Jung Kyong, et al.
Publicado: (2022)

Neoadjuvant chemoradiotherapy determines the prognostic impact of anastomotic leakage in advanced rectal cancer
por: Oh, Bo Young, et al.
Publicado: (2022)

Are We Predicting Disease Progress of the Rectal Cancer Patients without Surgery after Neoadjuvant Chemoradiotherapy?
por: Oh, Bo Young, et al.
Publicado: (2018)

Clinical Outcomes of Local Excision Following Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer
por: Lee, Nam Kwon, et al.
Publicado: (2014)

Is Preoperative Chemoradiotherapy Beneficial for Sphincter Preservation in Low-Lying Rectal Cancer Patients?
por: Park, In Ja, et al.
Publicado: (2016)

What Is the Ideal Tumor Regression Grading System in Rectal Cancer Patients after Preoperative Chemoradiotherapy?
por: Kim, Soo Hee, et al.
Publicado: (2016)

Outcome of Local Excision Following Preoperative Chemoradiotherapy for Clinically T2 Distal Rectal Cancer: A Multicenter Retrospective Study (KROG 12-06)
por: Noh, Jae Myoung, et al.
Publicado: (2014)

Correlation between tumor regression grade and rectal volume in neoadjuvant concurrent chemoradiotherapy for rectal cancer
por: Lee, Hong Seok, et al.
Publicado: (2016)

Influence of Preoperative Chemoradiotherapy on the Surgical Strategy According to the Clinical T Stage of Patients With Rectal Cancer
por: Park, In Ja, et al.
Publicado: (2015)

Minimally invasive versus open intersphincteric resection of low rectal cancer regardless of neoadjuvant chemoradiotherapy: long-term oncologic outcomes
por: Shin, Jung kyong, et al.
Publicado: (2021)

Clinical outcomes of chemoradiotherapy for locally recurrent rectal cancer
por: Lee, Joo Ho, et al.
Publicado: (2011)

Redefining the Positive Circumferential Resection Margin by Incorporating Preoperative Chemoradiotherapy Treatment Response in Locally Advanced Rectal Cancer: A Multicenter Validation Study
por: Lee, Joo Ho, et al.
Publicado: (2018)

Elevated CEA is associated with worse survival in recurrent rectal cancer
por: Cho, Won Kyung, et al.
Publicado: (2017)

Efficacy of preoperative chemoradiotherapy in patients with cT2N0 distal rectal cancer
por: Park, Min Young, et al.
Publicado: (2023)

Robotic Versus Laparoscopic Surgery for Rectal Cancer after Preoperative Chemoradiotherapy: Case-Matched Study of Short-Term Outcomes
por: Kim, Yong Sok, et al.
Publicado: (2016)

Retrospective study of preoperative chemoradiotherapy with capecitabine versus capecitabine plus oxaliplatin for locally advanced rectal cancer
por: Yang, Xiao-Hui, et al.
Publicado: (2020)

Comparison of capecitabine and 5-fluorouracil in chemoradiotherapy for locally advanced pancreatic cancer
por: Kim, Yeon-Joo, et al.
Publicado: (2013)

Prospective phase II trial of pazopanib plus CapeOX (capecitabine and oxaliplatin) in previously untreated patients with advanced gastric cancer
por: Kim, Seung Tae, et al.
Publicado: (2016)

Short-term outcomes after laparoscopic surgery following preoperative chemoradiotherapy for rectal cancer
por: Ahn, Byong Hyon, et al.
Publicado: (2012)

Clinical Significance of Tumor Regression Grade in Rectal Cancer with Preoperative Chemoradiotherapy
por: Park, Young Joo, et al.
Publicado: (2010)

A Nomogram for Predicting Pathological Complete Response to Neoadjuvant Chemoradiotherapy Using Semiquantitative Parameters Derived From Sequential PET/CT in Locally Advanced Rectal Cancer
por: Pyo, Dae Hee, et al.
Publicado: (2021)

Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy
por: Oh, Seul Gi, et al.
Publicado: (2020)

Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy
por: Il Yu, Jeong, et al.
Publicado: (2016)

Oncologic Outcomes of Organ Preserving Approaches in Patients With Rectal Cancer Treated With Preoperative Chemoradiotherapy
por: Park, In Ja, et al.
Publicado: (2019)

Changes in the Mean Corpuscular Volume after Capecitabine Treatment Are Associated with Clinical Response and Survival in Patients with Advanced Gastric Cancer
por: Jung, Hyun Ae, et al.
Publicado: (2015)

Capecitabine in combination with either cisplatin or weekly paclitaxel as a first-line treatment for metastatic esophageal squamous cell carcinoma: a randomized phase II study
por: Lee, Su Jin, et al.
Publicado: (2015)

Improvement in the Assessment of Response to Preoperative Chemoradiotherapy for Rectal Cancer Using Magnetic Resonance Imaging and a Multigene Biomarker
por: Cho, Eunhae, et al.
Publicado: (2021)

Phase I trial of capecitabine plus everolimus (RAD001) in patients with previously treated metastatic gastric cancer
por: Lim, Taekyu, et al.
Publicado: (2011)

Evaluating the benefit of adjuvant chemotherapy in patients with ypT0–1 rectal cancer treated with preoperative chemoradiotherapy
por: Jeon, Ye Won, et al.
Publicado: (2021)

Prediction of lateral pelvic lymph node metastasis in patients with locally advanced rectal cancer with preoperative chemoradiotherapy: Focus on MR imaging findings
por: Kim, Min Ju, et al.
Publicado: (2018)

Bevacizumab increases the risk of anastomosis site leakage in metastatic colorectal cancer
por: Kim, Seijong, et al.
Publicado: (2022)

Meta-Analysis on the Neutrophil-Lymphocyte Ratio in Rectal Cancer Treated With Preoperative Chemoradiotherapy: Prognostic Value of Pre- and Post-Chemoradiotherapy Neutrophil-Lymphocyte Ratio
por: Lee, Soo Jin, et al.
Publicado: (2022)

Clinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer
por: Choi, Chi Hwan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_rjh1ao5pc0440ev7cgtsqd019f