Cargando…

Melatonin Repairs Osteoporotic Bone Defects in Iron-Overloaded Rats through PI3K/AKT/GSK-3β/P70S6k Signaling Pathway

It was found recently that iron overload can cause osteoporosis in rats. Through in vitro and in vivo experimentations, the purpose of the present study was to validate and confirm the inhibitory effects of melatonin on iron death of osteoporosis and its role in bone microstructure improvements. Mel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Maoxian, Liu, Hedong, Jiang, Wenkai, Zhou, Zhi, Yao, Xuewei, Liu, Zhiyi, Ma, Nengfeng, Chen, Bing, Yang, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873465/ https://www.ncbi.nlm.nih.gov/pubmed/36703914 http://dx.doi.org/10.1155/2023/7718155

Ejemplares similares

Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity
por: Liu, Xunxian
Publicado: (2014)

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
por: Matsuda, Satoru, et al.
Publicado: (2019)

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
por: Kitagishi, Yasuko, et al.
Publicado: (2014)

Role of PI3K/Akt/GSK-3 Pathway in Emesis and Potential New Antiemetics
por: Zhong, W, et al.
Publicado: (2020)

Arctiin attenuates iron overload-induced osteoporosis by regulating the PI3K/Akt pathway
por: Li, Miao, et al.
Publicado: (2023)

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
por: Yang, Liying, et al.
Publicado: (2018)

Protective Effect of Minocycline Against Ketamine-Induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 Beta Pathway
por: Lu, Yang, et al.
Publicado: (2016)

Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
por: Kitagishi, Yasuko, et al.
Publicado: (2012)

Salvigenin Suppresses Hepatocellular Carcinoma Glycolysis and Chemoresistance Through Inactivating the PI3K/AKT/GSK-3β Pathway
por: Shao, Hui, et al.
Publicado: (2023)

Phosphorylated GSK-3β protects stress-induced apoptosis of myoblasts via the PI3K/Akt signaling pathway
por: Liu, Meixi, et al.
Publicado: (2020)

25-OH-PPD inhibits hypertrophy on diabetic cardiomyopathy via the PI3k/Akt/GSK-3β signaling pathway
por: Liu, Xinyu, et al.
Publicado: (2020)

Insensitivity of PI3K/Akt/GSK3 signaling in peripheral blood mononuclear cells of age-related macular degeneration patients
por: Liu, Xunxian, et al.
Publicado: (2017)

Involvement of GSK-3β Phosphorylation Through PI3-K/Akt in Cerebral Ischemia-Induced Neurogenesis in Rats
por: Kisoh, Keishi, et al.
Publicado: (2016)

LY3023414 inhibits both osteogenesis and osteoclastogenesis through the PI3K/Akt/GSK3 signalling pathway
por: Chen, Xiaojun, et al.
Publicado: (2021)

Piperine improves the sensitivity of osteosarcoma cells to doxorubicin by inducing apoptosis and inhibiting the PI3K/AKT/GSK-3β pathway
por: Qi, Yubin, et al.
Publicado: (2023)

Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells
por: Ren, Zhili, et al.
Publicado: (2020)

Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
por: Beker, Mustafa C., et al.
Publicado: (2019)

PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway
por: Zhong, Jiacheng, et al.
Publicado: (2023)

Discovery of an evodiamine derivative for PI3K/AKT/GSK3β pathway activation and AD pathology improvement in mouse models
por: Pang, Shuo, et al.
Publicado: (2023)

Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways
por: Yao, Mingyan, et al.
Publicado: (2021)

Role of TLR4-Mediated PI3K/AKT/GSK-3β Signaling Pathway in Apoptosis of Rat Hepatocytes
por: Zhang, Xian, et al.
Publicado: (2015)

Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway
por: Kong, Ning, et al.
Publicado: (2016)

Estradiol Activates PI3K/Akt/GSK3 Pathway Under Chronic Neurodegenerative Conditions Triggered by Perinatal Asphyxia
por: Saraceno, G. Ezequiel, et al.
Publicado: (2018)

Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3β Signaling Pathway
por: Bao, Zhong-Kun, et al.
Publicado: (2022)

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
por: Fan, Shengnuo, et al.
Publicado: (2015)

The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling
por: Zhu, Zhu, et al.
Publicado: (2019)

FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells
por: HALACLI, SEVIL OSKAY, et al.
Publicado: (2015)

Anticancer effect of the traditional Chinese medicine herb Maytenus compound via the EGFR/PI3K/AKT/GSK3β pathway
por: Zeng, Baozhen, et al.
Publicado: (2019)

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice
por: Yadav, Umesh C. S., et al.
Publicado: (2013)

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson's Disease: Involvement of the PI3K/Akt/GSK3β Pathway
por: Zhang, Wei, et al.
Publicado: (2016)

Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway
por: Wang, Dong, et al.
Publicado: (2017)

Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway
por: Kim, Sang-A, et al.
Publicado: (2018)

Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway
por: Zhang, Xian, et al.
Publicado: (2017)

Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway
por: Zhang, Ying, et al.
Publicado: (2020)

PPA1 Promotes Breast Cancer Proliferation and Metastasis Through PI3K/AKT/GSK3β Signaling Pathway
por: Guo, Chunlei, et al.
Publicado: (2021)

MALAT1 promotes platelet activity and thrombus formation through PI3k/Akt/GSK-3β signalling pathway
por: Sun, Yeying, et al.
Publicado: (2022)

K-ras/PI3K-Akt Signaling Is Essential for Zebrafish Hematopoiesis and Angiogenesis
por: Liu, Lihui, et al.
Publicado: (2008)

Baicalin Targets HSP70/90 to Regulate PKR/PI3K/AKT/eNOS Signaling Pathways
por: Hou, Yinzhu, et al.
Publicado: (2022)

Dec1 Deficiency Ameliorates Pulmonary Fibrosis Through the PI3K/AKT/GSK-3β/β-Catenin Integrated Signaling Pathway
por: Hu, Xingxing, et al.
Publicado: (2022)

Melatonin alleviates heat stress-induced testicular damage in dairy goats by inhibiting the PI3K/AKT signaling pathway
por: Liu, Yundie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h2tnl4d2cm21g7iv5597gt1uoj