Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits

Loss-of-function mutations of the gene Cul3 have been identified as a risk factor for autism-spectrum disorder (ASD), but the pathogenic mechanisms are not well understood. Conditional Cul3 ablation in cholinergic neurons of mice (Chat(CRE)Cul3(F/+)) recapitulated ASD-like social and sensory gating...

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Detalles Bibliográficos
Autores principales: Rapanelli, Maximiliano, Wang, Wei, Hurley, Edward, Feltri, Maria Laura, Pittenger, Christopher, Frick, Luciana Romina, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873627/
https://www.ncbi.nlm.nih.gov/pubmed/36693858
http://dx.doi.org/10.1038/s41398-023-02306-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873627/
https://www.ncbi.nlm.nih.gov/pubmed/36693858
http://dx.doi.org/10.1038/s41398-023-02306-8

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