Cargando…

DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma

Glioblastoma (GBM) currently has a dismal prognosis. GBM cells that survive radiotherapy contribute to tumor progression and recurrence with metabolic advantages. Here, we show that diacylglycerol kinase B (DGKB), a regulator of the intracellular concentration of diacylglycerol (DAG), is significant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Hyunkoo, Lee, Haksoo, Kim, Kyeongmin, Shin, Eunguk, Kim, Byeongsoo, Kang, JiHoon, Kim, Bohkyung, Lee, Jung Sub, Lee, Jae-Myung, Youn, HyeSook, Youn, BuHyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873821/ https://www.ncbi.nlm.nih.gov/pubmed/36603576 http://dx.doi.org/10.1016/j.xcrm.2022.100880

Ejemplares similares

Soybean-Derived Peptides Attenuate Hyperlipidemia by Regulating Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis
por: Lee, Haksoo, et al.
Publicado: (2021)

Targeting Glioblastoma Stem Cells to Overcome Chemoresistance: An Overview of Current Therapeutic Strategies
por: Kang, Hyunkoo, et al.
Publicado: (2022)

Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function
por: Kim, Kyeongmin, et al.
Publicado: (2021)

Downregulated CLIP3 induces radioresistance by enhancing stemness and glycolytic flux in glioblastoma
por: Kang, Hyunkoo, et al.
Publicado: (2021)

Organ-Specific Effects of Low Dose Radiation Exposure: A Comprehensive Review
por: Shin, Eunguk, et al.
Publicado: (2020)

Exosomal Plasminogen Activator Inhibitor-1 Induces Ionizing Radiation-Adaptive Glioblastoma Cachexia
por: Shin, Eunguk, et al.
Publicado: (2022)

Baiap3 regulates depressive behaviors in mice via attenuating dense core vesicle trafficking in subsets of prefrontal cortex neurons
por: Kim, Hyunwoo, et al.
Publicado: (2021)

BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling
por: Lee, Sungmin, et al.
Publicado: (2021)

NRBF2-mediated autophagy contributes to metabolite replenishment and radioresistance in glioblastoma
por: Kim, Jeongha, et al.
Publicado: (2022)

Role of Metabolic Reprogramming in Epithelial–Mesenchymal Transition (EMT)
por: Kang, Hyunkoo, et al.
Publicado: (2019)

Plasminogen activator inhibitor-1 enhances radioresistance and aggressiveness of non-small cell lung cancer cells
por: Kang, JiHoon, et al.
Publicado: (2016)

Revisiting Platinum-Based Anticancer Drugs to Overcome Gliomas
por: Jeon, Jaewan, et al.
Publicado: (2021)

Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy
por: Lee, Sungmin, et al.
Publicado: (2018)

Autophagic Organelles in DNA Damage Response
por: Kim, Jeongha, et al.
Publicado: (2021)

Cellular Stress Responses in Radiotherapy
por: Kim, Wanyeon, et al.
Publicado: (2019)

Investigation of Radiation-induced Transcriptome Profile of Radioresistant Non-small Cell Lung Cancer A549 Cells Using RNA-seq
por: Yang, Hee Jung, et al.
Publicado: (2013)

The Emerging Roles of Exosomes as EMT Regulators in Cancer
por: Kim, Hyunwoo, et al.
Publicado: (2020)

Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
por: Lee, Haksoo, et al.
Publicado: (2022)

RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis
por: Kim, Wanyeon, et al.
Publicado: (2018)

DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer
por: Kwon, TaeWoo, et al.
Publicado: (2016)

Inhibitory effect of traditional oriental medicine-derived monoamine oxidase B inhibitor on radioresistance of non-small cell lung cancer
por: Son, Beomseok, et al.
Publicado: (2016)

TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
por: Do, Hyunhee, et al.
Publicado: (2019)

The role of tumor microenvironment in therapeutic resistance
por: Son, Beomseok, et al.
Publicado: (2016)

TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial–mesenchymal transition
por: Kim, Wanyeon, et al.
Publicado: (2016)

TRAF4 promotes lung cancer aggressiveness by modulating tumor microenvironment in normal fibroblasts
por: Kim, EunGi, et al.
Publicado: (2017)

Radiation-induced overexpression of transthyretin inhibits retinol-mediated hippocampal neurogenesis
por: Kang, JiHoon, et al.
Publicado: (2018)

Long non-coding RNA in glioma: novel genetic players in temozolomide resistance
por: Roh, Jungwook, et al.
Publicado: (2023)

The miR‐126‐5p and miR‐212‐3p in the extracellular vesicles activate monocytes in the early stage of radiation‐induced vascular inflammation implicated in atherosclerosis
por: Choi, You Yeon, et al.
Publicado: (2023)

DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
por: Cheng, Xiang, et al.
Publicado: (2020)

MALAT1-regulated gene expression profiling in lung cancer cell lines
por: Roh, Jungwook, et al.
Publicado: (2023)

Hypolipidemic Roles of Casein-Derived Peptides by Regulation of Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis
por: Lee, Sungmin, et al.
Publicado: (2020)

Digoxin enhances radiation response in radioresistant A549 cells by reducing protein phosphatase 2A
por: Lee, Ji Young, et al.
Publicado: (2017)

Circular RNA DGKB Promotes the Progression of Neuroblastoma by Targeting miR-873/GLI1 Axis
por: Yang, Jiale, et al.
Publicado: (2020)

Inactivation of human DGAT2 by oxidative stress on cysteine residues
por: Jung, Sunhee, et al.
Publicado: (2017)

Dehydrozingerone inhibits renal lipotoxicity in high‐fat diet–induced obese mice
por: Lee, Eun Soo, et al.
Publicado: (2021)

The protective effects of steamed ginger on adipogenesis in 3T3-L1 cells and adiposity in diet-induced obese mice
por: Kim, Bohkyung, et al.
Publicado: (2021)

Inhibitory Effects of Ginsenoside Compound K on Lipopolysaccharide-Stimulated Inflammatory Responses in Macrophages by Regulating Sirtuin 1 and Histone Deacetylase 4
por: Kang, Hyunju, et al.
Publicado: (2023)

The Lactococcal dgkB (yecE) and dxsA Genes for Lipid Metabolism Are Involved in the Resistance to Cell Envelope-Acting Antimicrobials
por: Tymoszewska, Aleksandra, et al.
Publicado: (2021)

Bioactive Compounds as Inhibitors of Inflammation, Oxidative Stress and Metabolic Dysfunctions via Regulation of Cellular Redox Balance and Histone Acetylation State
por: Kang, Hyunju, et al.
Publicado: (2023)

The Usefulness of Stereotactic Radiosurgery for Radioresistant Brain Metastases
por: Kim, Hyool, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vi8ivsk9gjb9sa3569j2savao4