Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be achieved without chronic immunosuppression or encapsulation. Existing genetic engineering approaches to produce immune-evasive SC-islet cells have so far shown variable results. Here, we show that targetin...

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Detalles Bibliográficos
Autores principales: Gerace, Dario, Zhou, Quan, Kenty, Jennifer Hyoje-Ryu, Veres, Adrian, Sintov, Elad, Wang, Xi, Boulanger, Kyle R., Li, Hongfei, Melton, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873825/
https://www.ncbi.nlm.nih.gov/pubmed/36599351
http://dx.doi.org/10.1016/j.xcrm.2022.100879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873825/
https://www.ncbi.nlm.nih.gov/pubmed/36599351
http://dx.doi.org/10.1016/j.xcrm.2022.100879

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