Cargando…

Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be achieved without chronic immunosuppression or encapsulation. Existing genetic engineering approaches to produce immune-evasive SC-islet cells have so far shown variable results. Here, we show that targetin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gerace, Dario, Zhou, Quan, Kenty, Jennifer Hyoje-Ryu, Veres, Adrian, Sintov, Elad, Wang, Xi, Boulanger, Kyle R., Li, Hongfei, Melton, Douglas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873825/ https://www.ncbi.nlm.nih.gov/pubmed/36599351 http://dx.doi.org/10.1016/j.xcrm.2022.100879

Ejemplares similares

Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets
por: Sintov, Elad, et al.
Publicado: (2022)

Retrieval and purification of human β cells from stem cell-derived islet engrafted mice
por: Kenty, Jennifer Hyoje-Ryu, et al.
Publicado: (2021)

Cellular Immune Responses in Islet Xenograft Rejection
por: Hu, Min, et al.
Publicado: (2022)

Testing Pancreatic Islet Function at the Single Cell Level by Calcium Influx with Associated Marker Expression
por: Kenty, Jennifer H. R., et al.
Publicado: (2015)

Islet allografts expressing a PD‐L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression
por: Paul, Pradyut K., et al.
Publicado: (2022)

Islet transplantation into brown adipose tissue can delay immune rejection
por: Kepple, Jessica D., et al.
Publicado: (2022)

Evading the AAV Immune Response in Mucopolysaccharidoses
por: Piechnik, Matthew, et al.
Publicado: (2020)

Omicron evades immunity from vaccines
por: Onuora, Sarah
Publicado: (2022)

Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity
por: Bartel, Melissa, et al.
Publicado: (2011)

Fungal Strategies to Evade the Host Immune Recognition
por: Hernández-Chávez, Marco J., et al.
Publicado: (2017)

The Impact of Inflammation on the Immune Responses to Transplantation: Tolerance or Rejection?
por: Ravindranath, Mepur H., et al.
Publicado: (2021)

NKT cells reject islets
por: Van Epps, Heather L.
Publicado: (2005)

Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages
por: Abu Khweek, Arwa, et al.
Publicado: (2013)

Mechanisms by which Porphyromonas gingivalis evades innate immunity
por: Abdi, Kaveh, et al.
Publicado: (2017)

WNT Signaling in Tumors: The Way to Evade Drugs and Immunity
por: Martin-Orozco, Elena, et al.
Publicado: (2019)

Hepatitis C Virus: Evading the Intracellular Innate Immunity
por: Ferreira, Ana Rita, et al.
Publicado: (2020)

Insight into the mechanisms of coronaviruses evading host innate immunity
por: Yao, Tengteng, et al.
Publicado: (2023)

A machine learning approach to predict pancreatic islet grafts rejection versus tolerance
por: Ceballos, Gerardo A., et al.
Publicado: (2020)

Integrated Metabolomics and Proteomics Analyses in the Local Milieu of Islet Allografts in Rejection versus Tolerance
por: Hernandez, Luis F., et al.
Publicado: (2021)

Evading the Immune System: Immune Modulation and Immune Matching in Cell Replacement Therapies for Parkinson’s Disease
por: Morizane, Asuka, et al.
Publicado: (2021)

Pseudomonas Evades Immune Recognition of Flagellin in Both Mammals and Plants
por: Bardoel, Bart W., et al.
Publicado: (2011)

Parasite's Double Play Helps Evade Mouse Immune Response
por: Mejia, Robin
Publicado: (2012)

Encephalitozoon cuniculi takes advantage of efferocytosis to evade the immune response
por: Dalboni, Luciane Costa, et al.
Publicado: (2021)

Malaria oocysts require circumsporozoite protein to evade mosquito immunity
por: Zhu, Feng, et al.
Publicado: (2022)

Genetic Engineering of Immune Evasive Stem Cell-Derived Islets
por: Sackett, Sara D., et al.
Publicado: (2022)

Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity
por: Ren, Tao, et al.
Publicado: (2006)

Modeling rejection immunity
por: Gaetano, Andrea De, et al.
Publicado: (2012)

The specificity of rejection and the absence of susceptibility of pancreatic islet beta cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat
Publicado: (1989)

Induction of Immune Tolerance in Islet Transplantation Using Apoptotic Donor Leukocytes
por: Sato, Naoya, et al.
Publicado: (2021)

Engineered off-the-shelf therapeutic T cells resist host immune rejection
por: Mo, Feiyan, et al.
Publicado: (2020)

Redox-Dependent Inflammation in Islet Transplantation Rejection
por: Barra, Jessie M., et al.
Publicado: (2018)

Correction: Parasite's Double Play Helps Evade Mouse Immune Response
por: Mejia, Robin
Publicado: (2012)

Correction: Parasite's Double Play Helps Evade Mouse Immune Response
por: Mejia, Robin
Publicado: (2012)

Metastatic Melanoma Cells Evade Immune Detection by Silencing STAT1
por: Osborn, JoDi Lynn, et al.
Publicado: (2015)

Epstein-Barr virus: From kisses to cancer, an ingenious immune evader
por: Trivedi, Pankaj, et al.
Publicado: (2018)

The Different Tactics of Foot-and-Mouth Disease Virus to Evade Innate Immunity
por: Medina, Gisselle N., et al.
Publicado: (2018)

Evading plant immunity: feedback control of the T3SS in Pseudomonas syringae
por: Waite, Christopher, et al.
Publicado: (2017)

SARS‐CoV‐2 evades immune detection in alveolar macrophages
por: Dalskov, Louise, et al.
Publicado: (2020)

Tumors induce de novo steroid biosynthesis in T cells to evade immunity
por: Mahata, Bidesh, et al.
Publicado: (2020)

Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells
por: Desai, Prachi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k90c14f3pn0ffo8sg94egljmep