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Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus
B cells and autoantibodies have well-described pathological roles in systemic lupus erythematosus (SLE). Bradford et al.(1) now provide evidence that autoantibodies can also be protective by neutralizing type I interferons (IFNs) and restraining the activation of pathogenic B cells.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873922/ https://www.ncbi.nlm.nih.gov/pubmed/36652912 http://dx.doi.org/10.1016/j.xcrm.2022.100903 |
| _version_ | 1784877688393039872 |
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| author | Fillatreau, Simon |
| author_facet | Fillatreau, Simon |
| author_sort | Fillatreau, Simon |
| collection | PubMed |
| description | B cells and autoantibodies have well-described pathological roles in systemic lupus erythematosus (SLE). Bradford et al.(1) now provide evidence that autoantibodies can also be protective by neutralizing type I interferons (IFNs) and restraining the activation of pathogenic B cells. |
| format | Online Article Text |
| id | pubmed-9873922 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98739222023-01-26 Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus Fillatreau, Simon Cell Rep Med Preview B cells and autoantibodies have well-described pathological roles in systemic lupus erythematosus (SLE). Bradford et al.(1) now provide evidence that autoantibodies can also be protective by neutralizing type I interferons (IFNs) and restraining the activation of pathogenic B cells. Elsevier 2023-01-17 /pmc/articles/PMC9873922/ /pubmed/36652912 http://dx.doi.org/10.1016/j.xcrm.2022.100903 Text en © 2022 The Author https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preview Fillatreau, Simon Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus |
| title | Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus |
| title_full | Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus |
| title_fullStr | Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus |
| title_full_unstemmed | Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus |
| title_short | Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus |
| title_sort | antibodies against type i ifn: the bad guys self-restrain in systemic lupus erythematosus |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873922/ https://www.ncbi.nlm.nih.gov/pubmed/36652912 http://dx.doi.org/10.1016/j.xcrm.2022.100903 |
| work_keys_str_mv | AT fillatreausimon antibodiesagainsttypeiifnthebadguysselfrestraininsystemiclupuserythematosus |