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Size matters in non-canonical inflammasome activation and cell-mediated immunity
Particulate adjuvants are key components of many approved vaccines, but their mechanism of adjuvanticity is debated. Muñoz-Wolf et al.(1) find that 50-nm particles maximize cell-mediated immune responses by activating the caspase-11 inflammasome, providing mechanistic insight to particulate adjuvant...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873938/ https://www.ncbi.nlm.nih.gov/pubmed/36652913 http://dx.doi.org/10.1016/j.xcrm.2022.100904 |
| _version_ | 1784877692081930240 |
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| author | Weiss, Adam M. Esser-Kahn, Aaron P. |
| author_facet | Weiss, Adam M. Esser-Kahn, Aaron P. |
| author_sort | Weiss, Adam M. |
| collection | PubMed |
| description | Particulate adjuvants are key components of many approved vaccines, but their mechanism of adjuvanticity is debated. Muñoz-Wolf et al.(1) find that 50-nm particles maximize cell-mediated immune responses by activating the caspase-11 inflammasome, providing mechanistic insight to particulate adjuvant technologies. |
| format | Online Article Text |
| id | pubmed-9873938 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98739382023-01-26 Size matters in non-canonical inflammasome activation and cell-mediated immunity Weiss, Adam M. Esser-Kahn, Aaron P. Cell Rep Med Preview Particulate adjuvants are key components of many approved vaccines, but their mechanism of adjuvanticity is debated. Muñoz-Wolf et al.(1) find that 50-nm particles maximize cell-mediated immune responses by activating the caspase-11 inflammasome, providing mechanistic insight to particulate adjuvant technologies. Elsevier 2023-01-17 /pmc/articles/PMC9873938/ /pubmed/36652913 http://dx.doi.org/10.1016/j.xcrm.2022.100904 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Preview Weiss, Adam M. Esser-Kahn, Aaron P. Size matters in non-canonical inflammasome activation and cell-mediated immunity |
| title | Size matters in non-canonical inflammasome activation and cell-mediated immunity |
| title_full | Size matters in non-canonical inflammasome activation and cell-mediated immunity |
| title_fullStr | Size matters in non-canonical inflammasome activation and cell-mediated immunity |
| title_full_unstemmed | Size matters in non-canonical inflammasome activation and cell-mediated immunity |
| title_short | Size matters in non-canonical inflammasome activation and cell-mediated immunity |
| title_sort | size matters in non-canonical inflammasome activation and cell-mediated immunity |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873938/ https://www.ncbi.nlm.nih.gov/pubmed/36652913 http://dx.doi.org/10.1016/j.xcrm.2022.100904 |
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