Natural product manoalide promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK pathway and mitochondrial Ca(2+) overload-induced ferroptosis

Background: Manoalide (MA), a proven natural inhibitor of PLA2 has anticancer effects, but its potential application and mechanism as an anticancer drug to promote EGFR-TKI sensitivity in lung cancer cells have not been studied. Methods: KRAS-mutated lung cancer cells and organoids, acquired osimert...

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Detalles Bibliográficos
Autores principales: Ni, Yinyun, Liu, Jiaye, Zeng, Lingyan, Yang, Ying, Liu, Lei, Yao, Menglin, Chai, Li, Zhang, Lu, Li, Yi, Zhang, Li, Li, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873971/
https://www.ncbi.nlm.nih.gov/pubmed/36712673
http://dx.doi.org/10.3389/fphar.2022.1109822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873971/
https://www.ncbi.nlm.nih.gov/pubmed/36712673
http://dx.doi.org/10.3389/fphar.2022.1109822

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