Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s disease

Aberrant proteostasis is thought to be implicated in Parkinson’s disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation in the PD brain. We integrated transcriptomic and proteomic data from prefrontal...

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Detalles Bibliográficos
Autores principales: Dick, Fiona, Tysnes, Ole-Bjørn, Alves, Guido W., Nido, Gonzalo S., Tzoulis, Charalampos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874017/
https://www.ncbi.nlm.nih.gov/pubmed/36711240
http://dx.doi.org/10.1016/j.isci.2023.105925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874017/
https://www.ncbi.nlm.nih.gov/pubmed/36711240
http://dx.doi.org/10.1016/j.isci.2023.105925

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