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Molecular dynamics simulations of the calmodulin-induced α-helix in the SK2 calcium-gated potassium ion channel

The family of small-conductance Ca(2+)-activated potassium ion channels (SK channels) is composed of four members (SK1, SK2, SK3, and SK4) involved in neuron-firing regulation. The gating of these channels depends on the intracellular Ca(2+) concentration, and their sensitivity to this ion is provid...

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Detalles Bibliográficos
Autores principales: Ramis, Rafael, Ballesteros, Óscar R., Muguruza-Montero, Arantza, M-Alicante, Sara, Núñez, Eider, Villarroel, Álvaro, Leonardo, Aritz, Bergara, Aitor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874072/
https://www.ncbi.nlm.nih.gov/pubmed/36587765
http://dx.doi.org/10.1016/j.jbc.2022.102850