Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition

INTRODUCTION: Chronic Chagasic cardiomyopathy (CCC), caused by the protozoan Trypanosoma cruzi, is the most severe manifestation of Chagas disease.CCC is characterized by cardiac inflammation and fibrosis caused by a persistent inflammatory response. Following infection, macrophages secrete inflamma...

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Detalles Bibliográficos
Autores principales: González-Herrera, Fabiola, Clayton, Natasha S., Guzmán-Rivera, Daniela, Carrillo, Ileana, Castillo, Christian, Catalán, Mabel, Anfossi, Renatto, Quintero-Pertuz, Helena, Quilaqueo, María Elena, Olea-Azar, Claudio, Rivera-Meza, Mario, Kemmerling, Ulrike, Ridley, Anne J., Vivar, Raúl, Maya, Juan Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874148/
https://www.ncbi.nlm.nih.gov/pubmed/36713380
http://dx.doi.org/10.3389/fimmu.2022.1035589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874148/
https://www.ncbi.nlm.nih.gov/pubmed/36713380
http://dx.doi.org/10.3389/fimmu.2022.1035589

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