Cargando…

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry

Host cell entry of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is facilitated via priming of its spike glycoprotein by the human transmembrane protease serine 2 (TMPRSS2). Although camostat and nafamostat are two highly potent covalent TMPRSS2 inhibitors, they nevertheless did not h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moumbock, Aurélien F. A., Tran, Hoai T. T., Lamy, Evelyn, Günther, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874818/ https://www.ncbi.nlm.nih.gov/pubmed/36316225 http://dx.doi.org/10.1002/ardp.202200371

Ejemplares similares

CovPDB: a high-resolution coverage of the covalent protein–ligand interactome
por: Gao, Mingjie, et al.
Publicado: (2021)

Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies
por: Vargas-Alarcón, Gilberto, et al.
Publicado: (2020)

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
por: Koch, Jana, et al.
Publicado: (2021)

Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses
por: Sasaki, Michihito, et al.
Publicado: (2021)

Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat
por: Sun, Gaohui, et al.
Publicado: (2021)

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
por: Kishimoto, Mai, et al.
Publicado: (2021)

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2
por: Ou, Tianling, et al.
Publicado: (2021)

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2
por: Qiao, Yuanyuan, et al.
Publicado: (2021)

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease
por: Kreutzberger, Alex J. B., et al.
Publicado: (2021)

Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease
por: Kreutzberger, Alex J.B., et al.
Publicado: (2021)

Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs
por: Pierce, Jacob B., et al.
Publicado: (2020)

Synthesis, Structure, and Spectroscopy of the Biscarboranyl Stannylenes (bc)Sn·THF and K(2)[(bc)Sn](2) (bc = 1,1′(ortho-Biscarborane)) and Dibiscarboranyl Ethene (bc)CH=CH(bc)
por: Phung, Alice C., et al.
Publicado: (2023)

Correction to “Synthesis, Structure, and Spectroscopy of the Biscarboranyl Stannylenes (bc)Sn·THF and K(2)[(bc)Sn](2) (bc = 1,1′(ortho-Biscarborane)) and Dibiscarboranyl Ethene (bc)CH=CH(bc)”
por: Phung, Alice C., et al.
Publicado: (2023)

Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint
por: Kaur, Taruneet, et al.
Publicado: (2021)

Antiandrogens Target TMPRSS2 and Reduce SARS-CoV-2 Virus Entry in Lung Cells
por: Leach, Damien A, et al.
Publicado: (2021)

NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry
por: Han, Tianyu, et al.
Publicado: (2022)

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract
por: Liu, Yichuan, et al.
Publicado: (2020)

Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD
por: Burgueño, Juan F, et al.
Publicado: (2020)

Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes
por: Tran, Hoai T. T., et al.
Publicado: (2018)

Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
por: Hempel, Tim, et al.
Publicado: (2020)

Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges
por: Mahmoud, Ismail Sami, et al.
Publicado: (2021)

Exploring the phytochemicals of Platycodon grandiflorus for TMPRSS2 inhibition in the search for SARS-CoV-2 entry inhibitors
por: Gurung, Arun Bahadur, et al.
Publicado: (2022)

Co-expression of the SARS-CoV-2 entry receptors ACE2 and TMPRSS2 in healthy human conjunctiva
por: Mencucci, Rita, et al.
Publicado: (2021)

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry
por: Shirato, Kazuya, et al.
Publicado: (2018)

Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells
por: Vardhan, Seshu, et al.
Publicado: (2021)

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
por: Kettunen, Pinja, et al.
Publicado: (2023)

Azithromycin Downregulates Gene Expression of IL-1β and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2
por: Renteria, Axel E., et al.
Publicado: (2020)

The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
por: Leach, D. A., et al.
Publicado: (2021)

SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
por: Meng, Bo, et al.
Publicado: (2022)

Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells
por: Icho, Simoun, et al.
Publicado: (2022)

SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study
por: Baby, Krishnaprasad, et al.
Publicado: (2021)

Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin
por: Ouyang, Yingshi, et al.
Publicado: (2021)

The MAPK kinase BcMkk1 suppresses oxalic acid biosynthesis via impeding phosphorylation of BcRim15 by BcSch9 in Botrytis cinerea
por: Yin, Yanni, et al.
Publicado: (2018)

SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface
por: Chen, Wei, et al.
Publicado: (2020)

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
por: Hoffmann, Markus, et al.
Publicado: (2020)

Homology modeling of TMPRSS2 yields candidate drugs that may inhibit entry of SARS-CoV-2 into human cells.
por: Rensi, Stefano, et al.
Publicado: (2020)

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L
por: Prasad, Kartikay, et al.
Publicado: (2021)

In vitro Screening of Herbal Medicinal Products for Their Supportive Curing Potential in the Context of SARS-CoV-2
por: Tran, Hoai Thi Thu, et al.
Publicado: (2022)

Long-term exposure to “low-dose” bisphenol A decreases mitochondrial DNA copy number, and accelerates telomere shortening in human CD8 + T cells
por: Tran, Hoai Thi Thu, et al.
Publicado: (2020)

Contributions of human ACE2 and TMPRSS2 in determining host–pathogen interaction of COVID-19
por: SENAPATI, SABYASACHI, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hlpcvbhrs9al8nn40hfsagq3e1