Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes

Finnish-specific gene variant p.P50T/AKT2 (minor allele frequency (MAF) = 1.1%) is associated with insulin resistance and increased predisposition to type 2 diabetes. Here, we have investigated in vitro the impact of the gene variant on glucose metabolism and intracellular signalling in human primar...

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Detalles Bibliográficos
Autores principales: Mäkinen, Selina, Datta, Neeta, Rangarajan, Savithri, Nguyen, Yen H, Olkkonen, Vesa M, Latva-Rasku, Aino, Nuutila, Pirjo, Laakso, Markku, Koistinen, Heikki A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874976/
https://www.ncbi.nlm.nih.gov/pubmed/36409629
http://dx.doi.org/10.1530/JME-21-0285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874976/
https://www.ncbi.nlm.nih.gov/pubmed/36409629
http://dx.doi.org/10.1530/JME-21-0285

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