Cargando…

Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes

Finnish-specific gene variant p.P50T/AKT2 (minor allele frequency (MAF) = 1.1%) is associated with insulin resistance and increased predisposition to type 2 diabetes. Here, we have investigated in vitro the impact of the gene variant on glucose metabolism and intracellular signalling in human primar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mäkinen, Selina, Datta, Neeta, Rangarajan, Savithri, Nguyen, Yen H, Olkkonen, Vesa M, Latva-Rasku, Aino, Nuutila, Pirjo, Laakso, Markku, Koistinen, Heikki A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874976/ https://www.ncbi.nlm.nih.gov/pubmed/36409629 http://dx.doi.org/10.1530/JME-21-0285

Ejemplares similares

Brain insulin sensitivity is linked to body fat distribution—the positron emission tomography perspective
por: Rebelos, Eleni, et al.
Publicado: (2020)

SUN-657 The Effect of Simvastatin on Glucose Metabolism in Primary Human Muscle Cells
por: Mäkinen, Selina, et al.
Publicado: (2020)

Simvastatin profoundly impairs energy metabolism in primary human muscle cells
por: Mäkinen, Selina, et al.
Publicado: (2020)

ERRATUM: Simvastatin profoundly impairs energy metabolism in primary human muscle cells
por: Mäkinen, Selina, et al.
Publicado: (2022)

Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort
por: Rebelos, Eleni, et al.
Publicado: (2021)

Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study
por: Honka, Miikka-Juhani, et al.
Publicado: (2018)

Effects of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency, and myocardial contractile work in type 2 diabetes patients—a description of the DAPACARD study
por: Åkerblom, Axel, et al.
Publicado: (2019)

Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes
por: Öhman, Tiina, et al.
Publicado: (2021)

Angiopoietin-Like 4 Mediates PPAR Delta Effect on Lipoprotein Lipase-Dependent Fatty Acid Uptake but Not on Beta-Oxidation in Myotubes
por: Robciuc, Marius R., et al.
Publicado: (2012)

Obesity risk is associated with brain glucose uptake and insulin resistance
por: Pekkarinen, Laura, et al.
Publicado: (2022)

Predicting Skeletal Muscle and Whole-Body Insulin Sensitivity Using NMR-Metabolomic Profiling
por: Klén, Riku, et al.
Publicado: (2020)

Palmitate and oleate exert differential effects on insulin signalling and glucose uptake in human skeletal muscle cells
por: Mäkinen, Selina, et al.
Publicado: (2017)

Impact of Positive Family History and Genetic Risk Variants on the Incidence of Diabetes: The Finnish Diabetes Prevention Study
por: Uusitupa, Matti I., et al.
Publicado: (2011)

Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2009)

Insulin Secretion and Its Determinants in the Progression of Impaired Glucose Tolerance to Type 2 Diabetes in Impaired Glucose-Tolerant Individuals: The Finnish Diabetes Prevention Study
por: de Mello, Vanessa D.F., et al.
Publicado: (2012)

Chloroquine increases phosphorylation of AMPK and Akt in myotubes
por: Spears, Larry D., et al.
Publicado: (2016)

The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study
por: Jauhiainen, Raimo, et al.
Publicado: (2021)

The effects of acute hyperinsulinemia on bone metabolism
por: Ivaska, Kaisa K, et al.
Publicado: (2015)

Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort
por: Fizelova, Maria, et al.
Publicado: (2016)

Neural-level associations of non-verbal pragmatic comprehension in young Finnish autistic adults
por: Kotila, Aija, et al.
Publicado: (2021)

Gender Differences Relating to Metabolic Syndrome and Proinflammation in Finnish Subjects with Elevated Blood Pressure
por: Ahonen, Tiina, et al.
Publicado: (2009)

Novel biomarkers associated with incident heart failure in 10 106 Finnish men
por: Jauhiainen, Raimo, et al.
Publicado: (2020)

Differential activation of AKT isoforms by growth factors in human myotubes
por: Roberts, Brandon M., et al.
Publicado: (2023)

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: The Finnish Diabetes Prevention Study
por: Salopuro, Titta, et al.
Publicado: (2009)

The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy
por: Jørgenrud, Benedicte, et al.
Publicado: (2015)

Efficacy of the pentavalent rotavirus vaccine, RotaTeq®, in Finnish infants up to 3 years of age: the Finnish Extension Study
por: Vesikari, Timo, et al.
Publicado: (2010)

Leukocyte Telomere Length in the Finnish Diabetes Prevention Study
por: Hovatta, Iiris, et al.
Publicado: (2012)

Osteoprotegerin Is an Independent Predictor of Vascular Events in Finnish Adults With Type 1 Diabetes
por: Gordin, Daniel, et al.
Publicado: (2013)

Health-related quality of life and physical well-being among a 63-year-old cohort of women with androgenetic alopecia; a Finnish population-based study
por: Hirsso, Päivi, et al.
Publicado: (2005)

Perinatal outcomes in Finnish twins: a retrospective study
por: Rissanen, Annu-Riikka Susanna, et al.
Publicado: (2019)

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy
por: Jääskeläinen, Pertti, et al.
Publicado: (2019)

Leisure time physical activity in a 22-year follow-up among Finnish adults
por: Borodulin, Katja, et al.
Publicado: (2012)

Both Fasting and Glucose-Stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: A Population-Based Study of 9,396 Finnish Men
por: Vangipurapu, Jagadish, et al.
Publicado: (2015)

OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites
por: Olkkonen, Vesa M.
Publicado: (2015)

OSBP-Related Proteins: Liganding by Glycerophospholipids Opens New Insight into Their Function
por: Olkkonen, Vesa M.
Publicado: (2013)

Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2009)

Correction to: Perinatal outcomes in Finnish twins: a retrospective study
por: Rissanen, Annu-Riikka Susanna, et al.
Publicado: (2020)

Glycerol and Fatty Acids in Serum Predict the Development of Hyperglycemia and Type 2 Diabetes in Finnish Men
por: Mahendran, Yuvaraj, et al.
Publicado: (2013)

Leisure-Time Physical Activity and the Metabolic Syndrome in the Finnish Diabetes Prevention Study
por: Ilanne-Parikka, Pirjo, et al.
Publicado: (2010)

Making Sense of Science, University, and Industry: Sensemaking Narratives of Finnish and Israeli Scientists
por: Mäkinen, Elina I., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6ocqs1sl82476rg4ktlt7mqks1