PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development

Much of what is known about the mechanisms that control the developmental expression of the myelin proteolipid protein gene (PLP1) has been attained through use of transgenic animal models. In this study, we analyzed expression of related transgenes which utilize PLP1 genomic DNA from either human o...

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Detalles Bibliográficos
Autores principales: Patyal, Pankaj, Fil, Daniel, Hamdan, Hamdan, Wight, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875078/
https://www.ncbi.nlm.nih.gov/pubmed/36713780
http://dx.doi.org/10.3389/fncel.2022.1087145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875078/
https://www.ncbi.nlm.nih.gov/pubmed/36713780
http://dx.doi.org/10.3389/fncel.2022.1087145

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