Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

[Image: see text] Human sialic acid binding immunoglobulin-like lectin-8 (Siglec-8) is an inhibitory receptor that triggers eosinophil apoptosis and can inhibit mast cell degranulation when engaged by specific monoclonal antibodies (mAbs) or sialylated ligands. Thus, Siglec-8 has emerged as a critic...

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Detalles Bibliográficos
Autores principales: Lenza, Maria Pia, Atxabal, Unai, Nycholat, Corwin, Oyenarte, Iker, Franconetti, Antonio, Quintana, Jon Imanol, Delgado, Sandra, Núñez-Franco, Reyes, Garnica Marroquín, Carmen Teresa, Coelho, Helena, Unione, Luca, Jiménez-Oses, Gonzalo, Marcelo, Filipa, Schubert, Mario, Paulson, James C., Jiménez-Barbero, Jesús, Ereño-Orbea, June
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875244/
https://www.ncbi.nlm.nih.gov/pubmed/36711084
http://dx.doi.org/10.1021/jacsau.2c00592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875244/
https://www.ncbi.nlm.nih.gov/pubmed/36711084
http://dx.doi.org/10.1021/jacsau.2c00592

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