Cargando…

Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

[Image: see text] Human sialic acid binding immunoglobulin-like lectin-8 (Siglec-8) is an inhibitory receptor that triggers eosinophil apoptosis and can inhibit mast cell degranulation when engaged by specific monoclonal antibodies (mAbs) or sialylated ligands. Thus, Siglec-8 has emerged as a critic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lenza, Maria Pia, Atxabal, Unai, Nycholat, Corwin, Oyenarte, Iker, Franconetti, Antonio, Quintana, Jon Imanol, Delgado, Sandra, Núñez-Franco, Reyes, Garnica Marroquín, Carmen Teresa, Coelho, Helena, Unione, Luca, Jiménez-Oses, Gonzalo, Marcelo, Filipa, Schubert, Mario, Paulson, James C., Jiménez-Barbero, Jesús, Ereño-Orbea, June
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875244/ https://www.ncbi.nlm.nih.gov/pubmed/36711084 http://dx.doi.org/10.1021/jacsau.2c00592

Ejemplares similares

Current Status on Therapeutic Molecules Targeting Siglec Receptors
por: Lenza, María Pia, et al.
Publicado: (2020)

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
por: Lenza, Maria Pia, et al.
Publicado: (2023)

The SARS‐CoV‐2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View
por: Unione, Luca, et al.
Publicado: (2022)

Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human Lectins
por: Lenza, Maria Pia, et al.
Publicado: (2020)

Exploring multivalent carbohydrate–protein interactions by NMR
por: Quintana, Jon I., et al.
Publicado: (2023)

Enzymatic Synthesis of Trideuterated Sialosides
por: Cai, Zhi-P., et al.
Publicado: (2019)

Chemo-enzymatic synthesis of C-9 acetylated sialosides
por: Rauvolfova, Jana, et al.
Publicado: (2008)

Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides
por: Lin, Wei-Ling, et al.
Publicado: (2015)

Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection
por: Qing, Enya, et al.
Publicado: (2020)

Biocatalysis versus Molecular Recognition in Sialoside-Selective Neuraminidase Biosensing
por: Alshanski, Israel, et al.
Publicado: (2023)

Exploring Rigid and Flexible Core Trivalent Sialosides for Influenza Virus Inhibition
por: Kiran, Pallavi, et al.
Publicado: (2018)

Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc‐Containing Sugars: Modulation of the CH–π Stacking Interactions by Different Fluorination Patterns
por: Unione, Luca, et al.
Publicado: (2017)

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods
por: Stagnoli, Soledad, et al.
Publicado: (2022)

Glycoprofile Analysis of an Intact Glycoprotein As Inferred by NMR Spectroscopy
por: Unione, Luca, et al.
Publicado: (2019)

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
por: Park, Young-Jun, et al.
Publicado: (2019)

Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling
por: Soares, Cátia Oliveira, et al.
Publicado: (2021)

NMR Investigation of Protein‐Carbohydrate Interactions: The Recognition of Glycans by Galectins Engineered with Fluorotryptophan Residues
por: Lete, Marta G., et al.
Publicado: (2022)

Selective Exoenzymatic Labeling of Lipooligosaccharides of Neisseria gonorrhoeae with α2,6‐Sialoside Analogues
por: de Jong, Hanna, et al.
Publicado: (2022)

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants
por: Romerio, Alessio, et al.
Publicado: (2023)

Structural insight into the unique conformation of cystathionine β-synthase from Toxoplasma gondii
por: Fernández-Rodríguez, Carmen, et al.
Publicado: (2021)

The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba‐Mimetic
por: Calloni, Ilaria, et al.
Publicado: (2018)

Siglec-F is a novel intestinal M cell marker
por: Gicheva, Nadezhda, et al.
Publicado: (2016)

Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection
por: Stagnoli, Soledad, et al.
Publicado: (2023)

Antigen Delivery to Macrophages Using Liposomal Nanoparticles Targeting Sialoadhesin/CD169
por: Chen, Weihsu C., et al.
Publicado: (2012)

Siglec Ligands
por: Gonzalez-Gil, Anabel, et al.
Publicado: (2021)

The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoV
por: Awasthi, Mayanka, et al.
Publicado: (2020)

Sialosides Containing 7-N-Acetyl Sialic Acid Are Selective Substrates for Neuraminidases from Influenza A Viruses
por: Kooner, Anoopjit Singh, et al.
Publicado: (2022)

Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV)
por: Xie, Jiexiong, et al.
Publicado: (2017)

Oligosaccharide Presentation Modulates the Molecular Recognition of Glycolipids by Galectins on Membrane Surfaces
por: Lete, Marta G., et al.
Publicado: (2022)

The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery
por: Sommer, Roman, et al.
Publicado: (2016)

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates
por: Hayakawa, Toshiyuki, et al.
Publicado: (2017)

Ganglioside GM3 Analogues Containing Monofluoromethylene-Linked Sialoside: Synthesis, Stereochemical Effects, Conformational Behavior, and Biological Activities
por: Hirai, Go, et al.
Publicado: (2020)

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
por: Rodriguez, Ernesto, et al.
Publicado: (2021)

Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions
por: Franconetti, Antonio, et al.
Publicado: (2021)

Revealing the Specificity of Human H1 Influenza A Viruses to Complex N-Glycans
por: Canales, Angeles, et al.
Publicado: (2023)

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
por: Ereño-Orbea, June, et al.
Publicado: (2018)

Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens With Different Peripheral Core Presentations
por: Quintana, Jon I., et al.
Publicado: (2021)

Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways
por: Gonzalez-Gil, Anabel, et al.
Publicado: (2018)

Ab initio base fragment molecular orbital studies of influenza viral hemagglutinin HA1 full-domains in complex with sialoside receptors
por: Sawada, Toshihiko, et al.
Publicado: (2008)

Siglecs at the Host–Pathogen Interface
por: Chang, Yung-Chi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_eacjj96atvjfqm5ngehbj5s0fd