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Investigation of the Biosynthetic Mechanism of Bipentaromycin Featuring an Unprecedented Cyclic Head-to-Tail Dimeric Scaffold

[Image: see text] Bipentaromycins are heterodimeric aromatic polyketides featuring two distinctive 5/6/6/6/5 pentacyclic ring systems and exhibit antibacterial activities. However, their overall biosynthetic mechanism, particularly the mechanism for early-stage modifications, such as hydrogenation a...

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Detalles Bibliográficos
Autores principales: Huang, Chunshuai, Cui, Haiyang, Ren, Hengqian, Zhao, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875255/
https://www.ncbi.nlm.nih.gov/pubmed/36711095
http://dx.doi.org/10.1021/jacsau.2c00594