Recognition Mechanisms between a Nanobody and Disordered Epitopes of the Human Prion Protein: An Integrative Molecular Dynamics Study

[Image: see text] Immunotherapy using antibodies to target the aggregation of flexible proteins holds promise for therapeutic interventions in neurodegenerative diseases caused by protein misfolding. Prions or PrP(Sc), the causal agents of transmissible spongiform encephalopathies (TSE), represent a...

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Detalles Bibliográficos
Autores principales: Mollica, Luca, Giachin, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875307/
https://www.ncbi.nlm.nih.gov/pubmed/36580661
http://dx.doi.org/10.1021/acs.jcim.2c01062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875307/
https://www.ncbi.nlm.nih.gov/pubmed/36580661
http://dx.doi.org/10.1021/acs.jcim.2c01062

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