IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways

BACKGROUND: Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers. METHOD: This study investigated the effect and mechanism of IGF-1R in mediating the desensitization of hepatocellular...

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Detalles Bibliográficos
Autores principales: Cai, Wenpeng, Ma, Yongfang, Song, Li, Cao, Niandie, Gao, Jiafeng, Zhou, Shuping, Tang, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875405/
https://www.ncbi.nlm.nih.gov/pubmed/36698167
http://dx.doi.org/10.1186/s12885-023-10561-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875405/
https://www.ncbi.nlm.nih.gov/pubmed/36698167
http://dx.doi.org/10.1186/s12885-023-10561-7

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