SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice

Children with SOX2 deficiency develop ocular disorders and extra-ocular CNS anomalies. Animal data show that SOX2 is essential for retinal and neural stem cell development. In the CNS parenchyma, SOX2 is primarily expressed in astroglial and oligodendroglial cells. Here, we report a crucial role of...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Zhang, Sheng, Lan, Zhaohui, Doan, Vui, Kim, Bokyung, Liu, Sihan, Zhu, Meina, Hull, Vanessa L., Rihani, Sami, Zhang, Chun-Li, Gray, John A., Guo, Fuzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875714/
https://www.ncbi.nlm.nih.gov/pubmed/36543123
http://dx.doi.org/10.1016/j.celrep.2022.111842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875714/
https://www.ncbi.nlm.nih.gov/pubmed/36543123
http://dx.doi.org/10.1016/j.celrep.2022.111842

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