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SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice
Children with SOX2 deficiency develop ocular disorders and extra-ocular CNS anomalies. Animal data show that SOX2 is essential for retinal and neural stem cell development. In the CNS parenchyma, SOX2 is primarily expressed in astroglial and oligodendroglial cells. Here, we report a crucial role of...
Autores principales: | Wang, Yan, Zhang, Sheng, Lan, Zhaohui, Doan, Vui, Kim, Bokyung, Liu, Sihan, Zhu, Meina, Hull, Vanessa L., Rihani, Sami, Zhang, Chun-Li, Gray, John A., Guo, Fuzheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875714/ https://www.ncbi.nlm.nih.gov/pubmed/36543123 http://dx.doi.org/10.1016/j.celrep.2022.111842 |
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