Characterization of proteome-size scaling by integrative omics reveals mechanisms of proliferation control in cancer

Almost all living cells maintain size uniformity through successive divisions. Proteins that over and underscale with size can act as rheostats, which regulate cell cycle progression. Using a multiomic strategy, we leveraged the heterogeneity of melanoma cell lines to identify peptides, transcripts,...

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Detalles Bibliográficos
Autores principales: Jones, Ian, Dent, Lucas, Higo, Tomoaki, Roumeliotis, Theodoros, Arias Garcia, Maria, Shree, Hansa, Choudhary, Jyoti, Pedersen, Malin, Bakal, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876555/
https://www.ncbi.nlm.nih.gov/pubmed/36696495
http://dx.doi.org/10.1126/sciadv.add0636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876555/
https://www.ncbi.nlm.nih.gov/pubmed/36696495
http://dx.doi.org/10.1126/sciadv.add0636

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