Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility

Spermatozoa need to undergo an exocytotic event called the acrosome reaction before fusing with eggs. Although calcium ion (Ca(2+)) is essential for the acrosome reaction, its molecular mechanism remains unknown. Ferlin is a single transmembrane protein with multiple Ca(2+)-binding C2 domains, and t...

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Detalles Bibliográficos
Autores principales: Morohoshi, Akane, Miyata, Haruhiko, Tokuhiro, Keizo, Iida-Norita, Rie, Noda, Taichi, Fujihara, Yoshitaka, Ikawa, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876558/
https://www.ncbi.nlm.nih.gov/pubmed/36696506
http://dx.doi.org/10.1126/sciadv.ade7607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876558/
https://www.ncbi.nlm.nih.gov/pubmed/36696506
http://dx.doi.org/10.1126/sciadv.ade7607

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