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Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility
Spermatozoa need to undergo an exocytotic event called the acrosome reaction before fusing with eggs. Although calcium ion (Ca(2+)) is essential for the acrosome reaction, its molecular mechanism remains unknown. Ferlin is a single transmembrane protein with multiple Ca(2+)-binding C2 domains, and t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876558/ https://www.ncbi.nlm.nih.gov/pubmed/36696506 http://dx.doi.org/10.1126/sciadv.ade7607 |