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Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL
Single-cell barcoding technologies enable genome sequencing of thousands of individual cells in parallel, but with extremely low sequencing coverage (<0.05 [Formula: see text]) per cell. While the total copy number of large multi-megabase segments can be derived from such data, important allele-s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876616/ https://www.ncbi.nlm.nih.gov/pubmed/32879467 http://dx.doi.org/10.1038/s41587-020-0661-6 |