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Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL

Single-cell barcoding technologies enable genome sequencing of thousands of individual cells in parallel, but with extremely low sequencing coverage (<0.05 [Formula: see text]) per cell. While the total copy number of large multi-megabase segments can be derived from such data, important allele-s...

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Detalles Bibliográficos
Autores principales: Zaccaria, Simone, Raphael, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876616/
https://www.ncbi.nlm.nih.gov/pubmed/32879467
http://dx.doi.org/10.1038/s41587-020-0661-6

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