Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis

Doxorubicin (Dox) causes the generation of intracellular reactive oxygen species (ROS) and inactivates insulin-like growth factor 1 (IGF1) signaling, leading to cardiomyocyte apoptosis. IGF-binding protein 3 (IGFBP3) is the most abundant circulating IGF1 carrier protein with high affinity, which has...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Su-Ying, Ali, Ayaz, Huang, I-Chieh, Liu, Jian-Sheng, Chen, Po-Yuan, Padma Viswanadha, Vijaya, Huang, Chih-Yang, Kuo, Wei-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876638/
https://www.ncbi.nlm.nih.gov/pubmed/36602546
http://dx.doi.org/10.18632/aging.204466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876638/
https://www.ncbi.nlm.nih.gov/pubmed/36602546
http://dx.doi.org/10.18632/aging.204466

Ejemplares similares