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Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis

Doxorubicin (Dox) causes the generation of intracellular reactive oxygen species (ROS) and inactivates insulin-like growth factor 1 (IGF1) signaling, leading to cardiomyocyte apoptosis. IGF-binding protein 3 (IGFBP3) is the most abundant circulating IGF1 carrier protein with high affinity, which has...

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Detalles Bibliográficos
Autores principales:	Wen, Su-Ying, Ali, Ayaz, Huang, I-Chieh, Liu, Jian-Sheng, Chen, Po-Yuan, Padma Viswanadha, Vijaya, Huang, Chih-Yang, Kuo, Wei-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876638/ https://www.ncbi.nlm.nih.gov/pubmed/36602546 http://dx.doi.org/10.18632/aging.204466

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